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This second edition is a short and comprehensive study on the best
known approaches for preparing the main types of glycosides. It
covers synthetic pathways of challenging glycosides known as
antiviral or antineoplastic drugs, and synthetic substrates used
for enzymatic detection, including those used for detection of gene
markers in plant biotechnology. The author pays special attention
to the structural characterization of glycosides and provides the
basic tools for the structural assignment through NMR, X-Ray and
mass spectra techniques. The book also covers strategies for
preparation of antiviral and antineoplastic drugs included in a
drug design course.
This third edition is a comprehensive and extended study about the
best known approaches for preparing the main types of glycosides,
covering the classic and more recent glycosylation reactions used
for preparing simple and challenging glycosides currently used as
potent antiviral and antineoplastic drugs, or fluorogenic
substrates used for enzymatic detection in cell biology.
 Besides, this new edition provides more examples of the
glycosidic methodologies followed for preparing complex
glycoconjugates such as glycoproteins and glycosphingolipids and
gangliosides used as adjuvants or as synthetic vaccines candidates.
Also, additional mechanistic evidence is presented for better
understanding of the glycosylation reaction, trying to identify the
variables mainly depending on protecting and leaving groups, as
well as catalyst and reaction condition which altogether directs
the anomeric stereo control. A chapter on the glycoside hydrolysis
is included in view of the increasing interest in the use of
biomass as a natural and renewable source for obtaining important
intermediates or products used in food or valuable materials. The
author includes information in the characterization of glycosides
section with the aim of giving additional tools for the structural
assignment through NMR, X-Ray and mass spectra techniques.
This third edition is a comprehensive and extended study about the
best known approaches for preparing the main types of glycosides,
covering the classic and more recent glycosylation reactions used
for preparing simple and challenging glycosides currently used as
potent antiviral and antineoplastic drugs, or fluorogenic
substrates used for enzymatic detection in cell biology. Besides,
this new edition provides more examples of the glycosidic
methodologies followed for preparing complex glycoconjugates such
as glycoproteins and glycosphingolipids and gangliosides used as
adjuvants or as synthetic vaccines candidates. Also, additional
mechanistic evidence is presented for better understanding of the
glycosylation reaction, trying to identify the variables mainly
depending on protecting and leaving groups, as well as catalyst and
reaction condition which altogether directs the anomeric stereo
control. A chapter on the glycoside hydrolysis is included in view
of the increasing interest in the use of biomass as a natural and
renewable source for obtaining important intermediates or products
used in food or valuable materials. The author includes information
in the characterization of glycosides section with the aim of
giving additional tools for the structural assignment through NMR,
X-Ray and mass spectra techniques.
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